도파민 D4 수용체 길항제인 신규 피페라지닐프로필피라졸 유도체, 이의 제조방법 및 이를 포함하는 약학적 조성물
| 대표분류 | 화학 | ||
|---|---|---|---|
| 연구기관 | 한국화학연구원 | 연구자 | 박우규 |
| 기술내용 |
이전대상 특허번호: 2007-80052605(중국) 이전유형: 양도 기술료: 550만원(부가세포함) 비고: - The present invention relates to a novel piperazinyl-propyl-pyrazole derivative, a method of its preparation and a pharmaceutically acceptable composition comprising the same. The novel piperazinyl-propyl-pyrazole derivative of the present invention has superior selective affinity for dopamine D4 receptor, can effectively inhibit psychotic behavior (cage climbing) induced by apomorphine, and has relatively low adverse effects in mouse rotarod test. Therefore, it can be developed as a therapeutic agent for the treatment and prevention of central nervous system (CNS) disorders, in particular, schizophrenia, attention deficit hyperactivity disorder, depression, stress diseases, panic disorder, phobia, obsessive-compulsive disorder, posttraumatic stress disorder, cognitive disorder, Alzheimer's disease, Parkinson's disease, anxiety, paraphrenia, mania, seizure disorder, personality disorder, migraine, drug addiction, alcohol addiction, obesity, eating disorder, and sleeping disorder. |
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